Table 2.
Overall results of enrichment analysis using Enrichr.
| Index | Name | p-Value | Adjusted p-Value |
Odds Ratio | Combined Score |
|---|---|---|---|---|---|
| GO Biological Process | |||||
| 1 | chemical synaptic transmission (GO:0007268) | 5.186 × 10−29 | 1.086 × 10−25 | 22.00 | 1432.77 |
| 2 | anterograde trans-synaptic signaling (GO:0098916) | 3.609 × 10−25 | 3.778 × 10−22 | 22.43 | 1262.23 |
| 3 | modulation of chemical synaptic transmission (GO:0050804) | 3.001 × 10−20 | 2.095 × 10−17 | 33.15 | 1489.97 |
| 4 | glutamate receptor signaling pathway (GO:0007215) | 7.002 × 10−16 | 3.666 × 10−13 | 67.14 | 2343.00 |
| 5 | cellular response to cytokine stimulus (GO:0071345) | 2.163 × 10−15 | 9.060 × 10−13 | 9.56 | 322.96 |
| 6 | regulation of NMDA receptor activity (GO:2000310) | 8.579 × 10−15 | 2.994 × 10−12 | 71.58 | 2318.44 |
| 7 | positive regulation of gene expression (GO:0010628) | 2.058 × 10−14 | 5.422 × 10−12 | 9.08 | 286.14 |
| 8 | positive regulation of multicellular organismal process (GO:0051240) | 2.071 × 10−14 | 5.422 × 10−12 | 11.01 | 346.99 |
| 9 | calcium ion transmembrane import into cytosol (GO:0097553) | 1.848 × 10−13 | 4.224 × 10−11 | 49.19 | 1442.14 |
| 10 | negative regulation of apoptotic process (GO:0043066) | 2.117 × 10−13 | 4.224 × 10−11 | 8.55 | 249.46 |
| GO Molecular Function | |||||
| 1 | receptor ligand activity (GO:0048018) | 7.579 × 10−19 | 2.062 × 10−16 | 14.83 | 618.62 |
| 2 | glutamate receptor activity (GO:0008066) | 2.072 × 10−15 | 2.818 × 10−13 | 140.70 | 4757.03 |
| 3 | hormone activity (GO:0005179) | 5.605 × 10−15 | 5.081 × 10−13 | 32.19 | 1056.44 |
| 4 | ionotropic glutamate receptor activity (GO:0004970) | 8.568 × 10−14 | 5.826 × 10−12 | 137.88 | 4148.62 |
| 5 | glutamate-gated calcium ion channel activity (GO:0022849) | 1.350 × 10−11 | 7.344 × 10−10 | 99,320.00 | 2,485,812.34 |
| 6 | ligand-gated channel activity (GO:0022834) | 1.916 × 10−11 | 8.684 × 10−10 | 56.37 | 1391.10 |
| 7 | ligand-gated ion channel activity (GO:0015276) | 2.567 × 10−11 | 9.976 × 10−10 | 53.92 | 1314.77 |
| 8 | cytokine activity (GO:0005125) | 1.854 × 10−10 | 6.302 × 10−9 | 13.02 | 291.67 |
| 9 | NMDA glutamate receptor activity (GO:0004972) | 7.438 × 10−10 | 2.248 × 10−8 | 252.68 | 5311.25 |
| 10 | G protein-coupled glutamate receptor activity (GO:0001640) | 1.664 × 10−9 | 4.116 × 10−8 | 189.50 | 3830.60 |
| GO Cellular Component | |||||
| 1 | neuron projection (GO:0043005) | 3.351 × 10−24 | 4.290 × 10−22 | 12.87 | 695.42 |
| 2 | dendrite (GO:0030425) | 1.012 × 10−17 | 6.476 × 10−16 | 15.26 | 597.32 |
| 3 | ionotropic glutamate receptor complex (GO:0008328) | 5.840 × 10−13 | 2.170 × 10−11 | 61.13 | 1722.04 |
| 4 | axon (GO:0030424) | 6.781 × 10−13 | 2.170 × 10−11 | 13.95 | 391.00 |
| 5 | integral component of plasma membrane (GO:0005887) | 2.656 × 10−11 | 6.799 × 10−10 | 4.50 | 109.69 |
| 6 | postsynaptic density membrane (GO:0098839) | 4.142 × 10−11 | 8.836 × 10−10 | 82.86 | 1980.97 |
| 7 | postsynaptic specialization membrane (GO:0099634) | 6.178 × 10−11 | 1.130 × 10−9 | 76.94 | 1808.62 |
| 8 | NMDA selective glutamate receptor complex (GO:0017146) | 7.438 × 10−10 | 1.190 × 10−8 | 252.68 | 5311.25 |
| 9 | postsynaptic density (GO:0014069) | 2.637 × 10−9 | 3.750 × 10−8 | 13.68 | 270.15 |
| 10 | cation channel complex (GO:0034703) | 3.444 × 10−8 | 4.408 × 10−7 | 19.04 | 327.14 |