Table 2.
Clinical characteristics of overweight and obese children and adolescents stratified by NTS genotype.
| Genotypes | p | ||
|---|---|---|---|
| CC n = 594 |
CG+GG n = 338 |
||
| Sex (M vs. F) | 328/266 | 163/175 | 0.039 * |
| Age (years) | 10.4 ± 3.2 | 10.3 ± 3.2 | 0.769 |
| Tanner stage 1/≥2 | 299/289 | 168/169 § | 0.770 |
| Pro-NT (pmol/L) | 31.6 ± 20.8 | 22.2 ± 13.5 | 0.007 |
| BMI (kg/m2) | 27.6 ± 4.2 | 27.3 ± 4.8 | 0.327 |
| SDS-BMI | 2.1 ± 0.4 | 2 ± 0.4 | 0.062 |
| SBP (mm/Hg) | 106.2 ± 14.6 | 105.4 ± 14.9 | 0.398 |
| DBP (mm/Hg) | 62.2 ± 8.8 | 61 ± 8.7 | 0.046 |
| TC (mg/dL) | 168.3 ± 32.5 | 167.3 ± 32 | 0.193 |
| TG (mg/dL) | 63.1 ± 38.1 | 63.5 ± 41.4 | 0.881 |
| HDL-C (mg/dL) | 51.3 ± 12 | 51.6 ± 12.4 | 0.692 |
| LDL-C (mg/dL) | 104.3 ± 28.8 | 100.6 ± 26.6 | 0.043 |
| AST (U/L) | 24.7 ± 12 | 25.6 ± 5.9 | 0.318 |
| ALT (U/L) | 23.4 ± 11.7 | 22.4 ± 13.5 | 0.253 |
| FBG 0′ (mg/dL) | 89 ± 7.4 | 89 ± 8 | 0.899 |
| FBG 120′ (mg/dL) | 105.3 ± 17 | 106.5 ± 24.5 | 0.407 |
| FSI 0′ (μUI/mL) | 15.4 ± 9.5 | 14 ± 8.5 | 0.036 |
| FSI 120′ (μUI/mL) | 63.1 ± 53.5 | 60.7 ± 48.8 | 0.505 |
| HOMA-IR | 3.4 ± 2.2 | 3.1 ± 2 | 0.033 |
| HOMA-β | 223.8 ± 146 | 211.8 ± 233.6 | 0.037 |
| ISI | 6.7 ± 5.1 | 7.4 ± 6.4 | 0.068 |
| SPISE | 6.8 ± 1.6 | 6.9 ± 1.7 | 0.215 |
§ For 7 subjects, data are missing. Student’s t-test applied; * χ2 test applied. Abbreviations: CC, homozygous for C allele; CG, heterozygous carrying both C and G alleles; GG, homozygous for G allele; pro-NT, pro-neurotensin; BMI, body mass index; SDS BMI, standard deviation score of body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein; LDL-C, low-density lipoprotein; AST, alanine aminotransferase; ALT, aspartate aminotransferase; FBG, fasting blood glucose; FSI, fasting serum insulin; HOMA-IR, homeostatic model assessment of insulin resistance; HOMA-β, homeostatic model assessment for β-cell function; ISI, insulin-sensitivity index; SPISE, single-point insulin sensitivity estimator. TANNER I = pre-pubertal, TANNER ≥ II = pubertal stage.