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. 2023 Mar 29;13:1064343. doi: 10.3389/fonc.2023.1064343

Table 1.

Characteristics of Patients (n=448).

Characteristic NLR<2.81 NLR≥2.81 p PLR<168.24 PLR≥168.24 p LMR<5.46 LMR≥5.46 p
N 335 113 247 201 347 101
Sex 0.114 0.101 < 0.001
female 146 (32.6%) 39 (8.7%) 93 (20.8%) 92 (20.5%) 128 (28.6%) 57 (12.7%)
male 189 (42.2%) 74 (16.5%) 154 (34.4%) 109 (24.3%) 219 (48.9%) 44 (9.8%)
Age 1.000 0.006 1.000
<60 175 (39.1%) 59 (13.2%) 114 (25.4%) 120 (26.8%) 181 (40.4%) 53 (11.8%)
≥60 160 (35.7%) 54 (12.1%) 133 (29.7%) 81 (18.1%) 166 (37.1%) 48 (10.7%)
BMI 0.237 0.007 0.101
<25 243 (54.2%) 89 (19.9%) 170 (37.9%) 162 (36.2%) 264 (58.9%) 68 (15.2%)
≥25 92 (20.5%) 24 (5.4%) 77 (17.2%) 39 (8.7%) 83 (18.5%) 33 (7.4%)
Tumor Site 0.003 < 0.001 0.045
Colon 166 (37.1%) 75 (16.7%) 114 (25.4%) 127 (28.3%) 196 (43.8%) 45 (10%)
Rectum 169 (37.7%) 38 (8.5%) 133 (29.7%) 74 (16.5%) 151 (33.7%) 56 (12.5%)
Tumor Size 0.001 0.005 0.064
<5 202 (45.1%) 48 (10.7%) 153 (34.2%) 97 (21.7%) 185 (41.3%) 65 (14.5%)
≥5 133 (29.7%) 65 (14.5%) 94 (21%) 104 (23.2%) 162 (36.2%) 36 (8%)
Stage 0.520 0.117 0.263
I+II 191 (42.6%) 69 (15.4%) 152 (33.9%) 108 (24.1%) 196 (43.8%) 64 (14.3%)
III+IV 144 (32.1%) 44 (9.8%) 95 (21.2%) 93 (20.8%) 151 (33.7%) 37 (8.3%)
Grade 0.202 0.988 0.905
G1+G2 316 (70.5%) 102 (22.8%) 231 (51.6%) 187 (41.7%) 323 (72.1%) 95 (21.2%)
G3+M 19 (4.2%) 11 (2.5%) 16 (3.6%) 14 (3.1%) 24 (5.4%) 6 (1.3%)
NVI 0.454 0.699 0.494
No 208 (46.4%) 65 (14.5%) 153 (34.2%) 120 (26.8%) 208 (46.4%) 65 (14.5%)
Yes 127 (28.3%) 48 (10.7%) 94 (21%) 81 (18.1%) 139 (31%) 36 (8%)
CEA 0.770 0.685 1.000
<6.5 241 (53.8%) 79 (17.6%) 174 (38.8%) 146 (32.6%) 248 (55.4%) 72 (16.1%)
≥6.5 94 (21%) 34 (7.6%) 73 (16.3%) 55 (12.3%) 99 (22.1%) 29 (6.5%)
CA19-9 0.682 0.468 0.420
<27 266 (59.4%) 87 (19.4%) 191 (42.6%) 162 (36.2%) 270 (60.3%) 83 (18.5%)
≥27 69 (15.4%) 26 (5.8%) 56 (12.5%) 39 (8.7%) 77 (17.2%) 18 (4%)
Chemotherapy 0.030 0.002 0.821
No 178 (39.7%) 46 (10.3%) 140 (31.2%) 84 (18.8%) 172 (38.4%) 52 (11.6%)
Yes 157 (35%) 67 (15%) 107 (23.9%) 117 (26.1%) 175 (39.1%) 49 (10.9%)

NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; BMI, body mass index; M, Mucinous adenocarcinoma; NVI, nerve or vascular invasion; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19–9.