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. 2023 Mar 29;14:1133781. doi: 10.3389/fimmu.2023.1133781

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Copyright © 2023 Currenti, Simmons, Oakes, Gaudieri, Warren, Gangula, Alves, Ram, Leary, Armitage, Smith, Chopra, Halasa, Pilkinton and Kalams

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different transcriptional profile between resting and expanded cTfh cells. (A) Volcano plot comparing resting and expanded cTfh cells for all four subjects at d7. Significant DEGs by both p value and fold change are depicted in red. Horizontal and vertical dotted lines represent a significance threshold of p < 0.05 and a fold change of |1.5|, respectively. Significantly upregulated GO pathways for (B) resting and (C) expanded cTfh cells. Both the number of significant DEGs within each pathway and the p adjusted value are plotted. (D) Top 10 upstream regulators identified using DEGs for both resting (negative) and expanded (positive) cTfh cells, with pathways demonstrating significant alteration (z-score > |2|) depicted in red. (E) Mechanistic network for IFNG and their activation state in expanded cTfh cells based on ingenuity pathway analysis.