Table 3.
Cox regression model of factors associated with ILD in patients with RA.
| Dependent Variable | Predictor | HR | 95% CI | p Value |
|---|---|---|---|---|
| ILD | ||||
| DAS28-ESR, moderate-high activity | 2.474 | 1.173–5.220 | 0.017 | |
| High ACPA titer (>340) | 2.905 | 1.244–6.786 | 0.014 | |
| IL-18, pg/mL | 1.063 | 1.002–1.127 | 0.044 | |
| MCP-1/CCL2, pg/mL | 1.031 | 1.001–1.064 | 0.049 | |
| SDF-1 alpha, pg/mL | 1.001 | 1.001–1.002 | 0.010 |
Abbreviations: RA: rheumatoid arthritis; ILD: interstitial lung disease; DAS28-ESR: 28-joint Disease Activity Score with erythrocyte sedimentation rate; ACPA: anti–citrullinated peptide antibody; IL: interleukin. Variables included in the equation: age, sex, DAS28-ESR, high ACPA titer, IL-1 alpha, IL-18, IL-6, IL8 (CXCL8), MCP-1/CCL2, MCP-1/CCL4, SDF-1 alpha.