ASCVD	Atherosclerotic cardiovascular disease
ASGPRs	Asialoglycoprotein receptors
CKD	Chronic kidney disease
CRISPR	Clustered regularly interspaced short palindromic repeats
CVDs	Cardiovascular diseases
eNOS	Endothelial nitric oxide synthase
FH	Familial hypercholesterolemia
GalNAc	Triantennary N-acetylgalactosamine
HeFH	Heterozygous familial hypercholesterolemia
HMG-CoA	3-hydroxy-3-methylglutaryl-coenzyme A
HoFH	Homozygous familial hypercholesterolemia
IMPROVE-IT	The Improved Reduction of Outcomes: Vytorin Efficacy International Trial
LDL-C	Low-density lipoprotein cholesterol
LDLR	Low-density lipoprotein receptor
LDLRAP	Low-density lipoprotein receptor adaptor protein
mAb	Monoclonal antibody
MMPs	Matrix metalloproteinases
mRNA	Messenger ribonucleic acid
NHEJ	Nonhomologous end joining
PCSK9	Proprotein convertase subtilisin/kexin type 9
PREDIMED	PREvención con DIeta MEDiterránea
PROCAM	Prospective Cardiovascular Münster
RACING	Randomized comparison of efficacy and safety of lipid lowering with statin monotherapy versus statin–ezetimibe combination for high-risk cardiovascular disease
SCORE2	Systematic Coronary Risk Estimation 2
siRNA	Small interfering ribonucleic acid