Table 2.
Piezo1 channel associated diseases.
| Organ System | Affected Organs | Diseases | Affected Cell Type | Experimental Setup | References |
|---|---|---|---|---|---|
| Skeletal system | Bone | Osteoporosis | Osteocytes, osteoblasts | In vitro Human and mouse MSCs |
[147] |
| Bone | Osteosarcoma | Human osteosarcoma cells | In vitro Human osteosarcoma cell line MG63 and U2 cell line |
[148] | |
| Joints | Synovial sarcoma | SW982 cells | In vitro Human synovial sarcoma SW982, human embryonic kidney 293 cell lines |
[149] | |
| Joints | Joint disease | Chondrocytes | In vitro Primary chondrocytes from six-day-old mice |
[138] | |
| Dental system | Orthodontic tooth movement | Periodontal ligament cells | Sprague-Dawley rats (8 week old) | [131,150] | |
| Heart | Cardiovascular disease | Cardiac fibroblasts, cardiomyocytes | In vitro Knockout Mice sm22Cre Piezo1−/− Mice |
[151] | |
| Gastrointestinal system | Gastic region | Gastric cancer | Gastric cancer cell lines | In vitro Gastric cancer cell lines SGC-7901 and BGC-823 |
[152] |
| Pancreas | Pancreatitis | Pancreatic acinar cells | In vitro C57BL/6J male mice 6–8 week old and Piezo1 knockout mice: Ptf1atm2(cre/ESR1)Cvw/J mice |
[153] | |
| Pancreas | Pancreatic ductal adenocarcinoma | Pancreatic stellate cells | In vitro Human pancreatic cancer cell lines PCs, MiaPaCa-2 and Panc-1 |
[154] | |
| Excretory system | Bladder | Bladder dysfunction | Bladder urothelial cells | In vitro C57BL/6Cr) mice and TRPV4-knockout mice In vitro Patients with prostate cancer or benign prostatic hyperplasia |
[155] |
| Kidney | Renal fibrosis | HK2 cells | In vitro C57BL/6J mice In vitro Human kidney autopsy specimens Human proximal tubular cells (HK2 cells) |
[156] | |
| Respiratory system | Lungs | Acute respiratory distress syndrome | Type II pneumocytes | In vitro Health adult Sprague-Dawley rats |
[157] |
| Lungs | Lung capillary stress failure injury | Lung endothelial cells | In vitro Backcrossing Piezo1flox/flox mice with Endo-SCL-Cre mice |
[158] | |
| Lungs | Lung cancer | Small cell lung cancer lines | In vitro 16HBE cells |
[159] | |
| Nervous system | Central nervous system | Gliomas | Human gliomas cells | Human glioma tissues | [160,161] |
| Astrocytes | Neuroinflammation | Astrocytes | In vitro C57BL/6 mice; mixed glial cell cultures |
[162] | |
| Eye | Glaucoma | Cornea, retinal ganglion cell layer, and lens epithelial cells | In vitro 7-week-old male albino ddY mice, 15-month-old C57BL/6 mice, 9- and 15-month-old DBA/2J mice, adult Sprague–Dawley rats |
[163] | |
| Neurons | Migraine | Trigeminal ganglion | In vitro Wistar rats |
[164,165] | |
| Connective tissue | Skin | Hypertrophic scar | Myofibroblasts | In vitro Human hypertrophic scar tissues and adjacent normal skin tissues from 9 people |
[166] |
| Skin | Skin wound | Keratinocytes | In vitro Krt14Cre;Piezo1fl/fl (Piezo1-cKO) Krt14Cre;Piezo1cx/+ and Krt14Cre;Piezo1cx/cx (Piezo1-GoF) |
[167] | |
| Adipose tissue | Inflammation | Adipocytes | In vitro Piezo1-flox/flox mice were crossed to adiponectin-Cre mice |
[168] |