Table 1.

Common DEGs, altered in both CTRL vs. Aβ_1-42 and Aβ_1-42 vs. Δ⁸-THC + Aβ_1-42, related to “Alzheimer’s disease” (hsa05010) and “protein processing in endoplasmic reticulum” (hsa04141) pathways.

Gene	CTRL vs. Aβ1-42		Aβ1-42 vs. Δ8-THC + Aβ1-42		CTRL vs. Δ8-THC
	Fold Change	q-Value	Fold Change	q-Value	Fold Change	q-Value
ATF6	0.11	9.70 × 10−7	−0.11	9.51 × 10−08
BCL2	−0.45	1.74 × 10−17	0.33	1.08 × 10−10	−0.34	3.16 × 10−11
DNAJA2	−0.11	8.15 × 10−4	0.10	1.40 × 10−03
DNAJC1	0.21	1.51 × 10−3	−0.25	3.70 × 10−05
EDEM1	−0.29	3.16 × 10−9	0.17	4.10 × 10−04
EIF2AK4	0.15	1.51 × 10−15	−0.14	4.64 × 10−16	0.15	8.77 × 10−15
ERN1	0.37	1.46 × 10−6	−0.19	7.29 × 10−03
FBXO6	−1.21	2.21 × 10−4	1.52	3.86 × 10−07
HSP90AA1	0.06	3.31 × 10−33	0.01	5.68 × 10−03	0.11	3.57 × 10−129
HSP90AB1	0.04	2.31 × 10−25	−0.02	6.86 × 10−05	0.10	1.97 × 10−145
HSP90B1	0.06	2.20 × 10−12	−0.02	1.15 × 10−03	0.10	6.80 × 10−43
MAN1B1	0.10	1.70 × 10−8	−0.08	3.89 × 10−06
OS9	0.16	2.08 × 10−17	−0.12	3.05 × 10−12
PSMB4	−0.09	5.43 × 10−13	−0.06	4.45 × 10−06
PSMB5	−0.18	3.86 × 10−14	0.14	2.98 × 10−09	0.09	2.45 × 10−4
PSMB6	0.14	1.82 × 10−3	0.15	7.90 × 10−05	0.21	1.16 × 10−6
RAD23A	−0.15	2.61 × 10−6	0.09	4.40 × 10−03
SEC61B	0.12	1.06 × 10−3	−0.23	7.89 × 10−13
TXNDC5	−4.20	2.95 × 10−4	3.22	8.52 × 10−03
UBE2G2	−0.11	2.31 × 10−3	0.13	5.66 × 10−05
UBE2J1	−0.11	7.60 × 10−5	0.11	6.06 × 10−06
UBXN6	−0.11	4.66 × 10−5	0.11	1.41 × 10−05	0.08	2.60 × 10−3
UBXN8	−0.26	1.57 × 10−5	0.15	8.50 × 10−03

The column fold change shows for each DEG the difference in the level of expression computed by log₂(Aβ_1-42/CTRL), log₂(Δ⁸-THC + Aβ_1-42/Aβ_1-42) or log₂(Δ⁸-THC/CTRL). The q-Value column was obtained correcting the p-value through Benjamini–Hochberg correction. All values were rounded to the second decimal digit.