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Thumb subdomain position of RT in complex with approved or investigational NNRTIs. The structure of RT bound to 27 (PDB: 8FFX) is superimposed in green in each panel. Stars indicate complexes with measurable NNRTI Adjacent Site pocket volume (Table 4). Definitions: ETR—etravirine; DOR—doravirine; NVP—nevirapine; DEL—delavirdine; EFV—efavirenz; RPV—rilpivirine. Created with PyMOL and BioRender.com.
