Table 1.

Chemical structures, clogD, and IC₅₀s against P. falciparum D10 and W2 strains.

Structure	Compound	clogD a	P. falciparum D10 IC50 (µM) b	P. falciparum W2 IC50 (µM) b
	(5S, αS)-1a	0.02	0.35 ± 0.08	0.34 ± 0.12
	(5R, αS)-1b		23.54 ± 0.31	24.75 ± 0.90
	(5S, αR)-1c		7.49 ± 1.48	8.47 ± 2.06
	(5R, αR)-1d		8.79 ± 1.12	10.18 ± 1.75
	(5S, αS)-2a	0.04	0.79 ± 0.21	0.88 ± 0.23
	(5R, αS)-2b		17.14 ± 5.91	17.18 ± 7.39
	(5S, αR)-2c		40.67 ± 16.20	48.18 ± 14.81
	(5R, αR)-2d		8.27 ± 1.05	7.42 ± 3.54
	(5S, αS)-3a	1.41	0.37 ± 0.12	0.26 ± 0.05
	(5R, αS)-3b		32.65 ± 18.10	34.85 ± 5.30
	(5S, αR)-3c		19.35 ± 4.34	16.51 ± 8.11
	(5R, αR)-3d		4.31 ± 0.51	4.50 ± 1.82
	(5S, αS)-4a	0.76	0.36 ± 0.11	0.48 ± 0.18
	(5R, αS)-4b		18.20 ± 1.15	18.20 ± 0.93
	(5S, αR)-4c		19.35 ± 2.15	19.35 ± 3.36
	(5R, αR)-4d		8.55 ± 1.95	8.91 ± 3.40

^a The clogD values (pH 7.4) were calculated by using ACD/pKa GALAS algorithm of ACD/Percepta software (ACD/Percepta, Advanced Chemistry Development, Inc., Toronto, ON, Canada, 2017, http://www.acdlabs.com (accessed on 5 September 2022). ^b pLDH method; data are the mean of three independent experiments ± SD; D10: CQ-susceptible P. falciparum strain; W2: CQ-resistant P. falciparum strain.