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. 2023 Apr 12;18(4):e0282042. doi: 10.1371/journal.pone.0282042

Table 4. Assessment of the performance of the optimized CDF model for various datasets.

Sample ratio = 1:1 (mean±S.D) Sample ratio = 1:10 (mean±S.D)
Activatory DTIs Inhibitory DTIs Activatory DTIs Inhibitory DTIs
AUROC AUPR AUROC AUPR AUROC AUPR AUROC AUPR
Original dataset 0.880±0.029 0.899±0.019 0.935±0.003 0.946±0.003 0.873±0.007 0.629±0.033 0.939±0.004 0.780±0.007
Additional dataset 0.873±0.011 0.869±0.013 0.953±0.002 0.957±0.002 0.864±0.012 0.430±0.030 0.955±0.002 0.800±0.008
Separate model* 0.875±0.011 0.878±0.011 0.944±0.002 0.952±0.002 0.867±0.009 0.488±0.022 0.947±0.002 0.790±0.004
Integrated model# 0.875±0.010 0.881±0.008 0.943±0.002 0.951±0.001 0.869±0.008 0.489±0.023 0.946±0.002 0.786±0.005

Boldface indicates the highest value for each performance metric between the separate model and integrative model.

*Models trained on the original and additional datasets separately.

#Models trained on an integrated dataset.