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Structure of phenylglycine-based inhibitors and radiolabeled analogs. (A) Structure of preclinical and clinical mIDH1-selective inhibitors with an N-acetyl phenylglycine amide backbone (highlighted in blue) [65,70,71,73]. (B) Overview of radiolabeled phenylglycine-based inhibitors of mIDH1 (radiolabels highlighted in red) [62,74].
