Table 1.

Effects of sesamin, episesamin, and their metabolites on proliferative capacity.

Treatment Group		PDL
Late passage	-	73.2 ± 0.44
Sesamin	1 μM	73.6 ± 0.47
Epiesamin	1 μM	73.6 ± 0.45
SC1	100 nM	73.4 ± 0.37
	1 μM	74.5 ± 0.57 *
EC1-2	100 nM	72.3 ± 0.76
	1 μM	74.5 ± 0.32 *

PDL40 human lung fibroblast TIG-3 cells were cultured in DMEM to which the above compounds were added. Cells were treated with the test substance from the start of culture (PDL40), and the test substance was added regularly until proliferation in the late passage group ceased PDL was calculated as log2 (D/D0), with D and D0 defined as the cell number at the time of harvesting and the time of seeding, respectively. The data are reported as means ± SD of three independent experiments. *; p < 0.05 vs. Late passage group by Dunnett’s test.