Abstract
Retrospective cohort studies are increasingly being applied in occupational health. To describe and investigate further this type of study 179 retrospective cohort studies published in six scientific journals between 1975 and 1985 inclusive were reviewed. A description of the 179 reviewed articles was made and relations between investigator orientated variables, design characteristics, and the outcome of the study were investigated. Retrospective cohort studies focusing on exposures in the chemical industry appeared to yield most negative findings, which is partly explained by the relation between the affiliation of the investigator and the outcome of the study. Studies requiring a minimal latency period, an occupational reference group, and a low percentage of lost to follow up tended to have a higher chance of a positive finding. Study size, however, did not appear to be related to the outcome.
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Selected References
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- Bell C. M., Coleman D. A. Predicted mortality patterns in cohort study populations exposed to different types of hazard: can SMRs show a dose-response? Stat Med. 1983 Jul-Sep;2(3):363–371. doi: 10.1002/sim.4780020308. [DOI] [PubMed] [Google Scholar]
- Doll R. Occupational cancer: problems in interpreting human evidence. Ann Occup Hyg. 1984;28(3):291–305. doi: 10.1093/annhyg/28.3.291. [DOI] [PubMed] [Google Scholar]
- Enterline P. E. Pitfalls in epidemiological research. An examination of the asbestos literature. J Occup Med. 1976 Mar;18(3):150–156. [PubMed] [Google Scholar]
- Fox A. J., Collier P. F. Low mortality rates in industrial cohort studies due to selection for work and survival in the industry. Br J Prev Soc Med. 1976 Dec;30(4):225–230. doi: 10.1136/jech.30.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaffey W. R. A critique of the standardized mortality ratio. J Occup Med. 1976 Mar;18(3):157–160. doi: 10.1097/00043764-197603000-00007. [DOI] [PubMed] [Google Scholar]
- Hernberg S. "Negative" results in cohort studies--how to recognize fallacies. Scand J Work Environ Health. 1981;7 (Suppl 4):121–126. [PubMed] [Google Scholar]
- McMichael A. J. Standardized mortality ratios and the "healthy worker effect": Scratching beneath the surface. J Occup Med. 1976 Mar;18(3):165–168. doi: 10.1097/00043764-197603000-00009. [DOI] [PubMed] [Google Scholar]
- Shindell S., Weisberg R. F., Giefer E. E. The "healthy worker effect"--fact or artifact? J Occup Med. 1978 Dec;20(12):807–811. [PubMed] [Google Scholar]
- Wang J. D., Miettinen O. S. Occupational mortality studies. Principles of validity. Scand J Work Environ Health. 1982 Sep;8(3):153–158. doi: 10.5271/sjweh.2480. [DOI] [PubMed] [Google Scholar]
- Wong O., Decoufle P. Methodological issues involving the standardized mortality ratio and proportionate mortality ratio in occupational studies. J Occup Med. 1982 Apr;24(4):299–304. [PubMed] [Google Scholar]