Table 2.
The stability assessment of MAC glucuronide phenol linked SN-38 in mouse plasma (n = 3).
Assessment | Statistics | Low QC (400 ng/mL) |
Medium QC (2000 ng/mL) |
High QC (8000 ng/mL) |
---|---|---|---|---|
Short-term stability |
Mean concentration | 362.18 | 1917.73 | 8152.33 |
Accuracy (%) | 90.54 | 95.89 | 101.90 | |
Precision (%, CV) | 12.15 | 17.46 | 6.62 | |
Long-term stability |
Mean concentration | 446.90 | 1724.19 | 6159.21 |
Accuracy (%) | 111.73 | 86.21 | 76.99 | |
Precision (%, CV) | 8.23 | 3.17 | 3.02 | |
Freeze-thaw stability |
Mean concentration | 484.37 | 1969.98 | 8172.28 |
Accuracy (%) | 121.09 | 98.50 | 102.15 | |
Precision (%, CV) | 1.84 | 8.64 | 12.78 |