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. 2023 Apr 1;15(7):1737. doi: 10.3390/nu15071737

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of L. plantarum CCFM405 on dopaminergic neurons and neurotransmitters in the striatum of rotenone-challenged PD mice. (A) Representative images of TH immunohistochemistry in the left and right substantia nigra. Scale (left: 50 μm right: 500 μm) (n = 3/group); (B) quantitative evaluation of average optical density (OD) of TH positive area in the left and right substantia nigra (n = 3/group); The concentrations of neurotransmitters in the unilateral striatu (C) DA, dopamine; (D) DOPAC, 3,4-dihydroxyphenylacetic acid; (E) HVA, homovanillic acid; (F) 5-HT, 5-hydroxytryptamine; (G) 5-HIAA, 5-hydroxyindoleacetic acid. n = 8/group. Data are means with SEM. ## p < 0.01 signs Rotenone + Saline group vs. CMC-Na + Saline group; * p < 0.05 signs Rotenone+CCFM405 group vs. Rotenone+Saline grup.