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. 2023 Mar 26;15(7):1609. doi: 10.3390/nu15071609

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of probiotic combinations on inflammation and oxidative stress in the brains of naturally aged mice. (A–C) Pathological sections (400×) of the CA1 region of the hippocampus of each group of mice, where (A) indicates control group C, (B) indicates low-dose intervention group L, and (C) indicates high-dose intervention group H. (D–F) Effect of the complex probiotics on antioxidant activity in the brains of naturally aged mice, showing the changes in MDA (D), T-SOD (E), T-AOC (F), and GSH-Px (G). (H,I) Changes in the effect of probiotic combinations on brain inflammation in naturally aged mice results show changes IL-6 (H) and CRP (I). * indicates p < 0.05; ** indicates p < 0.01.