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. 2023 Apr 5;15(7):1771. doi: 10.3390/nu15071771

Figure 1.

Figure 1

PG accelerated the recovery phase of acute colitis, promoting the mucosal epithelial barrier repair. (A) Body weight and (B) bleeding score were evaluated in the DSS-induced colitis model during the acute phase induced by 3% DSS administered ad libitum for 5 days and during the recovery phase replacing DSS treatment with regular water and treating mice with PG or saline. (C) Colon length (cm) was measured in PG- and saline-treated mice. (D) Intestinal wall damage of untreated colitic mice and of PG- and saline-treated mice were monitored by endoscopic evaluation. (E) Multiplex bead-based assay was performed on healthy and PG- and saline-treated mice. Levels (PG/mL) of KC, MCP1, IL-5, IL-10, IL-6, TNF-α, INF-γ, IL12p70, IL12p40, IL-17, and IL13 were evaluated. Data are presented as mean ± SEM. Unpaired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001. n = 6 mice/PG group, n = 5 mice/saline group, n = 3 mice/healthy group.