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. Author manuscript; available in PMC: 2023 Apr 12.
Published in final edited form as: Neuroimage. 2022 Jul 22;261:119503. doi: 10.1016/j.neuroimage.2022.119503

Table 1.

Cohort characteristics

Characteristic HA cohort MS/HC cohort
CIS RRMS SPMS HC-CIS HC-RRMS HC-SPMS All patients All HC
Total cohort
No. 170 40 40 40 40 40 40 120 120
Age, yrs (mean±SD [range]) 39±17
(9–81)		 37±10
(20–58)		 44±10
(27–65)		 52±7
(33–64)		 37±12
(20–59)		 43±10
(19–60)		 53±12
(23–76)		 44±11
(20–65)		 45±13
(19–76)
Sex, no.
 Female 85 29 27 29 28 30 29 85 88
 Male 85 11 13 11 12 10 11 35 33
dd, yrs (mean±SD) 2.2±2.6 9.8±6.0 24.0±10.2 12.1±11.3
EDSS (median [range]) 1.5
(0–4.5)		 2.0
(0–8)		 6.5
(2.5–8)		 2.5
(0–8)
ICA final cohort
No. 166 40 40 38 39 37 39 118 115
Age, yrs (mean±SD [range]) 39±16
(9–81)		 37±10
(20–58)		 44±10
(27–65)		 52±7
(33–64)		 37±12
(20–59)		 43±10
(19–60)		 52±12
(23–76)		 44±11
(20–65)		 44±13
(19–76)
Sex, no.
 Female 83 29 27 29 27 28 28 85 83
 Male 83 11 13 9 12 9 11 33 32
dd, yrs (mean±SD) 2.2±2.6 9.8±6.0 24.1±10.1 11.7±11.3
EDSS (median [range]) 1.5
(0–4.5)		 2.0
(0–8)		 6.5
(2.5–8)		 2.5
(0–8)
Regression cohort
No. 70 30 31 30 32 28 33 91 93
Age, yrs (mean±SD [range]) 44±15
(12–76)		 38±11
(20–58)		 44±10
(27–65)		 53±7
(33–64)		 37±12
(20–59)		 43±10
(19–60)		 52±11
(26–76)		 45±11
(20–65)		 44±13
(19–76)
Sex, no.
 Female 39 23 19 22 22 18 25 64 65
 Male 31 7 12 8 10 10 8 27 28
Systolic BP (mean±SD) 131±14 133±19 137±21 140±22 132±15 133±18 131±16 137±21 132±16
BMI (mean±SD) 27.0±5.9 26.4±6.1 26.8±6.3 25.5±4.3 25.4±5.4 28.7±5.8 26.5±5.4 26.2±5.6 26.8±5.6
Current smoker
 Yes 14 2 3 1 0 1 0 6 1
 No 56 28 28 29 32 27 33 85 92
Reported migraines
 Yes 13 3 5 3 7 9 4 11 20
 No 57 27 26 27 25 19 29 80 73
dd, yrs (mean±SD) 2.0±2.4 10.0±6.3 25.1±9.3 12.4±11.6
EDSS (median [range]) 1.5
(0–4.5)		 2.5
(0–8)		 6.1
(2.5–8)		 3.3
(0–8)