Table 2.
Results of exploratory DGM network regression models
| Variable | Network for HA cohorta | Network for MS-only cohorta | ||||
|---|---|---|---|---|---|---|
| Dorsal striatum | GPi | GPi | Pulvinar | Caudate | Mesencephalon | |
| Adjusted R2 | 0.175 | 0.194 | 0.171 | 0.234 | 0.096 | 0.039 |
| Age |
1.176
(0.004) ** |
0.377
(0.004) ** |
0.098 (0.524) |
−0.037 (0.795) |
0.228 (0.146) |
0.083 (0.588) |
| Sex |
0.811
(0.022) * |
−0.060 (0.598) |
0.122 (0.239) |
0.067 (0.497) |
0.066 (0.552) |
0.153 (0.175) |
| Age × Sex | −1.162 (0.021)* |
n.s. | n.s. | n.s. | n.s | n.s. |
| Systolic BP | 0.075 (0.511) |
0.211 (0.085) |
−0.003 (0.976) |
−0.194 (0.079) |
−0.117 (0.361) |
−0.097 (0.478) |
| BMI | 0.176 (0.115) |
0.017 (0.886) |
−0.129 (0.219) |
0.028 (0.764) |
0.031 (0.771) |
0.021 (0.856) |
| Smoking | 0.052 (0.651) |
−0.212 (0.086) |
0.197 (0.066) |
−0.091 (0.369) |
0.103 (0.371) |
0.095 (0.410) |
| Migraine | 0.061 (0.594) |
0.285
(0.022) * |
0.050 (0.645) |
0.088 (0.391) |
−0.090 (0.439) |
0.100 (0.390) |
| dd | - | - | −0.003 (0.986) |
-0.488 (0.005)** |
0.076 (0.680) |
0.291 (0.141) |
| T2 lesion volume | - | - | 0.161 (0.131) |
0.047 (0.643) |
0.272
(0.018) * |
0.288
(0.013) * |
| EDSS | - | - | 0.306 (0.080) |
0.106 (0.518) |
0.113 (0.545) |
0.361 (0.057) |
a
Standardized beta values are given with uncorrected P values below in parentheses. Significant effects are bolded. “n.s.” indicates a nonsignificant age × sex term that was removed from the final model.
*
P < 0.05
**
P < 0.01.