Table 1.
Patient characteristics, patients aged ≥ 60 years with Clostridioides difficile infection in the Central Denmark Region in the period from 1 January to 31 December 2018
| n (%) | |
|---|---|
| Total, N | 457 (100) |
| Age groups (years) | |
| 60–69 | 118 (25) |
| 70–79 | 158 (35) |
| 80–max | 181 (40) |
| Severity | |
| Mild | 33 (7) |
| Severe | 189 (41) |
| Fulminant | 190 (42) |
| Unknown | 45 (10) |
| Frailty level | |
| Low (MPI-1) | 80 (18) |
| Moderate (MPI-2) | 136 (30) |
| Severe (MPI-3) | 171 (37) |
| Unknown | 70 (15) |
| Gender, n (%) | |
| Female | 223 (49) |
| Habitation status | |
| Living in own home | 384 (84) |
| Nursing home resident | 73 (16) |
| CDI diagnose, site | |
| Primary healthcare | 14 (3) |
| Outpatients | 56 (12) |
| Inpatients | 387 (85) |
| Primary disease requiring admission | |
| Clostridioides difficile | 86 (19) |
| Other enteral infectious disease | 14 (3) |
| Urinary tract infection | 20 (4) |
| Sepsis | 27 (6) |
| Erysipelas | 3 (1) |
| Viral infectious disease | 4 (1) |
| Pneumonia | 51 (11) |
| Chronic Obstructive Pulmonary disease | 20 (4) |
| Cardiovascular disease | 13 (3) |
| Endocrine disease | 6 (1) |
| Dehydration and electrolyte disturbance | 14 (3) |
| Gastrointestinal disease | 31 (7) |
| Renal disease | 9 (2) |
| Rheumatic disease | 12 (3) |
| Anaemia | 3 (1) |
| Central nervous system disease | 5 (1) |
| Delirium | 2 (0,5) |
| Other skin diseases | 2 (0,5) |
| Lesions and intoxication | 20 (4) |
| Cancer | 15 (3) |
| Other | 30 (7) |
| Unknown | 70 (15) |
| Toxin profile | |
| Toxin A/B | 455 (99) |
| Binary toxin | 75 (16) |
| Subtype 027 | 2 (0.4) |
| CDI definitiona | |
| Healthcare facility-onset (HO) | 193 (42) |
| Community-onset, healthcare facility-associated (COHCFA) | 137 (30) |
| Community-associated (CA) | 127 (28) |
| Treatment at index CDI, n (%) | |
| No treatment | 55 (12) |
| Metronidazole | 257 (56) |
| Vancomycin | 69 (15) |
| Metronidazole + Vancomycin | 69 (15) |
| Vancomycin + Fidaxomicin | 3 (0.7) |
| Vancomycin + Feacal microbiota transplantation | 4 (0.9) |
CDI Clostridioides difficile infection, MPI multidimensional prognostic index
aHO: case of CDI collected > 3 days after admission to facility; CO-HCFA: case of CDI occurring within 28 days after discharge from a healthcare facility; CA: case of CDI occurring more than 28 days after discharge from a healthcare facility