Table 2.
90-Day mortality and hazard ratio estimates for age, severity and frailty of Clostridioides difficile infection
| Total, n (%) |
Death within 90 days, n (%) | Crude HR (95% CI) |
P-value | Adjusted HR (95% CI)a | P-value | |
|---|---|---|---|---|---|---|
| Total | N = 457 | 127 (28) | – | – | – | – |
| Age groups (years) | ||||||
| 60–69 | 118 (25) | 20/118 (17) | 1.00 (reference) | – | 1.00 (reference) | – |
| 70–79 | 158 (35) | 37/158 (23) | 1.46 (0.85–2.51) | 0.175 | 1.48 (0.86–2.55) | 0.162 |
| 80-max | 181 (40) | 70/181 (39) | 2.67 (1.62–4.38) | < 0.001 | 2.71 (1.64–4.47) | < 0.001 |
| Severity (N = 412) | ||||||
| Severeb | 222 (54) | 31/222 (14) | 1.00 (reference) | – | 1.00 (reference) | – |
| Fulminant | 190 (46) | 94/190 (49) | 4.69 (3.12–7.05) | < 0.001 | 4.58 (3.04–6.88) | < 0.001 |
| Frailty level (N = 387) | ||||||
| Low (MPI-1) | 80 (18) | 5/80 (6) | 1.00 (reference) | – | 1.00 (reference) | – |
| Moderate (MPI-2) | 136 (30) | 25/136 (18) | 3.10 (1.19–8.10) | 0.021 | 2.70 (1.03–7.11) | 0.044 |
| Severe (MPI-3) | 171 (37) | 88/171 (51) | 11.32 (4.60–27.90) | < 0.001 | 10.15 (4.06–25.36) | < 0.001 |
| Unknown | 70 (15) | 9/70 (13) | – | – | – | – |
Patients with unknown MPI or CDI severity were not included in the analysis, but separate sensitivity analyses were made
CDI Clostridioides difficile infection, MPI multidimensional prognostic index
aAdjusted for age and gender. Age groups only adjusted for gender
bMild (n = 33) and severe (n = 189) CDI were merged