Extended Data Fig. 10. Model for protein delivery via reprogrammed PVCs.

In this work, we demonstrated that PVCs can be engineered 1.) to load and deliver diverse novel payloads, enabling the introduction of novel biological activity into target cells, and 2.) to target novel organisms, enabling the delivery of human cells and live mice with high efficiency and specificity. We conclude that PVCs constitute a new class of highly programmable protein delivery devices.