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. 2023 Feb 27;616(7956):326–331. doi: 10.1038/s41586-023-05862-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Phylogenetic tree of 198 proteins with predicted homology to Vs.4 identified in Prokaryotic Virus Remote Homologous Groups database (see Methods). b, Vs.4 homologs were aligned with clustal omega and the multiple sequence alignment is shown. The sequence of Vs.4 from T4 phage is displayed on the x-axis. Insertions in the alignment are denoted with dashes. Residues in the cGAMP binding site are indicated with an *.