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. 2023 Apr 12;14:2084. doi: 10.1038/s41467-023-37685-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Repeated measurements of biomarker concentrations in plasma of iNPH showed different profiles depending on the biomarker examined: A Aβ40 (P = 0.039), B Aβ42 (P = 0.055), C Aβ42/ Aβ40 ratio (P = 0.134), D T-tau (P < 0.001), E GFAP (P = 0.072), and F NfL (P = 0.030; regression analysis). The profile of daytime variation for IIH subjects differed: G Aβ40 (P = 0.0.049), H Aβ42 (P = 0.035), I Aβ42/ Aβ40 ratio (P = 0.304), J T-tau (P = 0.130), K GFAP (P = 0.026), and L NfL (P = 0.193; fractional polynomial regression analysis with robust standard error for repeated measurements). Results presented as mean (red line) with 95% confidence intervals (red shaded area), including individual data points. Source data are provided as Source Data file.