The osmotic laxative polyethylene glycol is recommended as the drug of first choice for both disimpaction and maintenance treatment of pediatric functional constipation.

Alternative or additional pharmacological treatment options consist of other osmotic laxatives, stimulant laxatives, lubricants, and several types of enemas.

Novel drugs, such as lubiprostone, linaclotide, prucalopride, elobixibat, and pyridostigmine, show promising results in adults. Because of a lack of evidence in the pediatric population, these drugs are not yet included in international guidelines for children with functional constipation.