Table 1.

PICOS selection criteria

Criterium	Inclusion
Population	Children and adults with drug-induced HPL
Intervention	Drug treatment known or suspected to induce HPL
Comparator	Any or no comparator
Outcomes	Clinical presentation, including symptoms and signs of druginduced HPL, such as reproductive dysfunction, sexual impairment, breast dysfunctions, abnormalities associated with chronic hypogonadism, behavioural and mood alterations
	Long-term complications of drug-induced HPL
Study design	Interventional and non-interventional studies: • Non-interventional/observational studies (prospective, retrospective, cross-sectional studies) • Interventional studies (randomised and non-randomised clinical trials)

HPL hyperprolactinaemia, PICOS populations, interventions and comparators, outcomes, and study design