Abstract
The physical chemical factors controlling partition coefficients between air, water, blood, and various tissues are discussed. It is suggested that improved insights into the relations between partition coefficients, which are frequently expressed as correlations, may be obtained by viewing the partition coefficients as ratios of solubilities or pseudosolubilities. A simple, novel correlation approach is developed and applied to 24 volatile organic chemicals, which enables tissue/blood, tissue/air, and blood/air partition coefficients to be estimated from water solubility and vapour pressure. An illustration is presented in which these solubilities are used to calculate the equilibrium distribution of dichloromethane between air, blood, and various tissues.
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Selected References
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- Abraham M. H., Kamlet M. J., Taft R. W., Doherty R. M., Weathersby P. K. Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids. J Med Chem. 1985 Jul;28(7):865–870. doi: 10.1021/jm00145a004. [DOI] [PubMed] [Google Scholar]
- Andersen M. E., Clewell H. J., 3rd, Gargas M. L., Smith F. A., Reitz R. H. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol Appl Pharmacol. 1987 Feb;87(2):185–205. doi: 10.1016/0041-008x(87)90281-x. [DOI] [PubMed] [Google Scholar]
- Fiserova-Bergerova V., Diaz M. L. Determination and prediction of tissue-gas partition coefficients. Int Arch Occup Environ Health. 1986;58(1):75–87. doi: 10.1007/BF00378543. [DOI] [PubMed] [Google Scholar]
- Perbellini L., Brugnone F., Caretta D., Maranelli G. Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues. Br J Ind Med. 1985 Mar;42(3):162–167. doi: 10.1136/oem.42.3.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ramsey J. C., Andersen M. E. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol Appl Pharmacol. 1984 Mar 30;73(1):159–175. doi: 10.1016/0041-008x(84)90064-4. [DOI] [PubMed] [Google Scholar]
- Sato A., Nakajima T. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Br J Ind Med. 1979 Aug;36(3):231–234. doi: 10.1136/oem.36.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]