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. 2023 Apr 12;14:2066. doi: 10.1038/s41467-023-37589-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative FACS plots showing expression of UEA1 and Ly51 by total EpCAM1⁺ cells, K19^-EpCAM1⁺ cells and K19⁺EpCAM1⁺ cells at E15.5, and corresponding quantitation (n = 12, from 3 independent experiments). Data analysed using a Student’s t-test. b Representative FACS plots showing expression of MHCII and CD80 to define mTEC^neg (MHCII^-CD80^-), mTEC^int (MHCII^intCD80^int) and mTEC^hi (MHCII^hiCD80^hi), and the corresponding expression of K19 by these subsets (upper panel), and expression of Aire within mTEC^hi, and the corresponding expression of K19 by Aire⁺ mTEC^hi (lower panel). Bar chart shows proportion of K19⁺ cells within mTEC^neg, mTEC^int, and mTEC^hi at E15.5 (n = 12, from 3 independent experiments). Data analysed using a one-way ANOVA, with Bonferroni post hoc test. c Representative FACS plots showing expression of MHCII within UEA1^-Ly51⁺ cells, and expression of K19 by these subpopulations. Bar chart shows proportion of K19⁺ cells within MHCII^-UEA1^-Ly51⁺ and MHCII⁺UEA1^-Ly51⁺ TEC at E15.5 (n = 12, from 3 independent experiments). Data analysed using a Student’s t test. The data are shown as mean ± SEM.