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The weaknesses existing in current PDX models. a Tumor stroma tends to be replaced by murine-derived ECM and stromal cells after several passages, which hinders immune cell activation without human cytokine secretion. b Loss of subclones heterogeneity during the establishment and passage of PDX. c PDX mice have a relatively high risk of spontaneous lymphoma which could cover up accurate results due to the distinct drug sensitivities between lymphoma and other tumors
