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. 2023 Mar 30;11:990725. doi: 10.3389/fped.2023.990725

Table 3.

Relationship between parental reproductive age and risk of EBP in offspring [OR (95% CI)].

Paternal age Model 1 Total Model 2
Maternal age P trend Maternal age P trend Total
≤26 26–32 >32 ≤26 26–32 >32
≤27 1.29 (1.19–1.39)* ** 1.00 (0.89–1.12) 0.97 (0.41–2.07) <0.001 1.27 (1.20–1.34)*** 1.18 (1.08–1.29)*** 0.96 (0.83–1.10) 1.18 (0.46–2.75) <0.001 1.18 (1.10–1.26)***
27–30 0.98 (0.89–1.08) 1.00 (ref) 1.12 (0.70–1.75) 0.64 1.00 (ref) 0.96 (0.86–1.07) 1.00 (ref) 0.96 (0.55–1.62) 0.39 1.00 (ref)
>30 0.77 (0.68–0.88)* ** 0.86 (0.78–0.94)** 1.35 (1.18–1.54)*** <0.001 0.91 (0.85–0.98)* 0.84 (0.73–0.97)* 0.88 (0.79–0.99)* 1.18 (1.01–1.38)* 0.02 0.93 (0.86–1.02)
P trend <0.001 0.002 0.29 <0.001 0.21 0.62
Total 1.27 (1.21–1.33)*** 1.00 (ref) 1.42 (1.26–1.59)*** 1.18 (1.11–1.25)*** 1.00 (ref) 1.23 (1.07–1.41)**

Model 1 adjusted for offspring age and sex.

Model 2 adjusted for offspring age, sex, province, school, breastfeeding, birth weight, gestational age, delivery mode, parental history of hypertension, parental highest education degree and offspring lifestyle score.

*

P < 0.05, **P < 0.01, ***P < 0.001.