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. 2023 Mar 30;14:1143966. doi: 10.3389/fphys.2023.1143966

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Copyright © 2023 Aas, Øvstebø, Brusletto, Aspelin, Trøseid, Qureshi, Eid, Olstad, Nyman and Haug.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panther classification and Ingenuity Pathway analysis (IPA) of extracellular vesicle proteins changed by EPS. Of the 73 proteins that were changed by EPS in exosomes, 60 were classified into protein classes by the Panther classification system (A). The top predicted canonical pathways of proteins regulated by EPS in exosomes assessed by IPA (B). Panther classification of 77 of the 95 proteins changed by EPS in MV (C), the top canonical pathways of the proteins changed by EPS in MV (D), and the proteins of the mitochondrial oxidative phosphorylation pathway activated by EPS in MV (E).