Table 1.
Detailed characteristics of each study.
| Study | Country | Modality/analysis | Diagnosis | Disease stage | Sample number | Mean Age ±SD | Male/Female | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| pHD | sHD | HC | pHD | sHD | HC | pHD | sHD | HC | |||||
| Wolf et al. (6) | Germany | MRI (3T,CASL)/rCBF | Gene testing | pHD | 18 | NA | 18 | 36.3 ± 9.0 | NA | 37.2 ± 10.3 | 8/10 | NA | 9/9 |
| Werner et al. (7) | Germany | rs-fMRI (3T)/ICA | Gene testing (CAG repeat expansion 40-49) | sHD | NA | 17 | 19 | NA | 44.9 ± 9.9 | 47.5 ± 10.1 | NA | 7/10 | 8/11 |
| Poudel et al. (8) | Australia | rs-fMRI (3T)/ICA | Gene testing | pHD&sHD | 25 | 23 | 18 | 42.9 ± 9.2 | 56.0 ± 9.4 | 45.5 ± 13.7 | 9/16 | 13/10 | 4/14 |
| Liu et al. (9) | China | rs-fMRI (3T)/ALFF | Gene testing | sHD | NA | 10 | 20 | NA | 45.0 ± 9.1 | 45.4 ± 8.4 | NA | 1/9 | 2/18 |
| Sarappa et al. (11) | Italy | rs-fMRI (3T)/fALFF, ReHo | Gene testing | pHD&sHD | 11 | 28 | 40 | 38.1 ± 7.1 | 41.6 ± 9.6 | 37.4 ± 13.5 | 5/6 | 17/11 | 18/22 |
| Harrington et al. (10) | USA | rs-fMRI (3T)/NBS | Gene testing | pHD | 48 | NA | 16 | 39.7 ± 10.4 | NA | 42.6 ± 9.2 | 8/40 | NA | 4/12 |
| Education years | CAG repeats number | UHDRS motor score | UHDRS cognitive score | Software | Atrophy correction | ||||||||
| pHD | sHD | HC | pHD | sHD | pHD | sHD | HC | pHD | sHD | HC | |||
| 14.7 ± 2.0 | NA | 15.1 ± 2.7 | 42.1 ± 3.1 | NA | 3.1 ± 3.0 | NA | NA | 329.8 ± 32.3 | NA | NA | SPM8 | No | |
| NA | NA | NA | NA | 44.2 ± 2.6 | NA | 31.1 ± 20.2 | 1.0 ± 1.0 | NA | 208.7 ± 81.1 | 319.3 ± 35.9 | MELODIC, FSL | Yes | |
| NA | NA | NA | 42.5 ± 1.9 | 42.6 ± 2.0 | 1.0 ± 1.2 | 26.5 ± 18.2 | NA | NA | NA | NA | SPM8, FSL | No | |
| NA | 10.4 ± 2.76 | NA | NA | 43.9 ± 4.2 | NA | 25.7 ± 15.2 | NA | NA | NA | NA | SPM8 | Yes | |
| NA | NA | NA | 46 (range 40–49) | 46 (range 42–65) | 1 (range 0–4) | 17 (range 5–53) | NA | 216 (106–324) | 166 (range 52–234) | NA | SPM8 | Yes | |
| 14.5 ± 2.4 | NA | 16.0 ± 1.9 | 42.7 ± 2.6 | NA | 7.3 ± 5.3 | NA | 5.1 ± 4.5 | NA | NA | NA | Not reported | No | |
CASL, continuous arterial spin labeling; pHD, premanifest HD; sHD, symptomatic HD; HC, healthy control; ALFF, Amplitude of Low Frequency Fluctuations; ReHo, regional homogeneity; ICA, independent component analysis; fALFF, fractional Amplitude of Low Frequency Fluctuations; NBS, network-based statistic; MELODIC, Multivariate Exploratory Linear Decomposition into Independent Components; SPM, Statistical Parametric Mappin; NA, not available.