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. 2023 Mar 30;14:1129245. doi: 10.3389/fimmu.2023.1129245

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Copyright © 2023 Esmagambetov, Ryabova, Derkaev, Shcheblyakov, Dolzhikova, Favorskaya, Grousova, Dovgiy, Prokofiev, Gosudarev, Byrikhina, Zorkov, Iliukhina, Kovyrshina, Shelkov, Naroditsky, Logunov and Gintsburg

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An overview of rAAV-P2C5-Fc preparation and analysis. (A) Structure of recombinant P2C5-Fc antibody: SP – amino acid sequence of signal peptide of IgG1 heavy chain; P2C5 – amino acid sequence of P2C5 single domain antibody; hinge – amino acid sequence of hinge region of IgG1; Fc fragment amino acid sequence Fc fragment of IgG1. (B) Schematics of rAAV-P2C5-Fc production and mechanism of action. (C) Evaluation of rAAV-P2C5-Fc transducing activity using HEK293 cells: bars indicate concentration of P2C5-Fc antibody in cultural media, cultivation time is shown by color. (D) SDS-PAGE of an rAAV-P2C5-Fc purity and authenticity analysis: M – protein molecular weight marker; 1, 2 fractions of purified rAAV-P2C5-Fc; VP1, VP2, VP3 rAAV capsid proteins.