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. 2023 Mar 30;14:1129245. doi: 10.3389/fimmu.2023.1129245

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Copyright © 2023 Esmagambetov, Ryabova, Derkaev, Shcheblyakov, Dolzhikova, Favorskaya, Grousova, Dovgiy, Prokofiev, Gosudarev, Byrikhina, Zorkov, Iliukhina, Kovyrshina, Shelkov, Naroditsky, Logunov and Gintsburg

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Evaluation of rAAV-P2C5-Fc optimal dose. (A) Scheme of the experiment: mice were treated with different doses of rAAV-P2C5-Fc and challenged with 10⁵ TCID50 SARS-CoV-2 B.1.1.1 variant on day 3 after the transduction. (B) Animal survival. (C) Body weight loss. Lines – mean values, error bars – SD, numbers indicate statistical significance evaluated compared with the vehicle group using a logrank test. Data from different rAAV-P2C5-Fc treatment groups are shown by color. Control, NSS – mice received normal saline solution. n – number of animals per group.