Figure 5.

Evaluation of long-term protective activity of rAAV-P2C5-Fc against SARS-CoV-2. (A) Scheme of the experiment: mice were treated with rAAV-P2C5-Fc at a dose of 2*10¹¹ gc/animal on days 60, 90, 140 before the challenge with SARS-CoV-2 B.1.1.1 variant at a dose of 10⁵ TCID50. (B) Viral load in the organs of animals infected with SARS-CoV-2 on day 140 after the treatment. (C) Animal survival. (D) Body weight loss. Lines – mean values, error bars – SD, numbers indicate statistical significance evaluated compared with the vehicle group using a logrank test (survival) or Mann–Whitney U test (viral load). Data from different treatment groups are shown by color. Control, NSS – mice received normal saline solution. n – number of animals per group. ** means statistically significant.