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. 2023 Mar 30;14:1129245. doi: 10.3389/fimmu.2023.1129245

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Copyright © 2023 Esmagambetov, Ryabova, Derkaev, Shcheblyakov, Dolzhikova, Favorskaya, Grousova, Dovgiy, Prokofiev, Gosudarev, Byrikhina, Zorkov, Iliukhina, Kovyrshina, Shelkov, Naroditsky, Logunov and Gintsburg

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Evaluation of blood serum samples collected from mice treated with rAAV-P2C5-Fc. (A) Scheme of the experiment: a single intramuscular injection of rAAV-P2C5-Fc at a dose of 2*10¹¹ gc/mouse was performed. Serum samples were taken at days 0, 1, 2, 3, 7, 14, 21, 45, 60, 90, 120, 150, 180, 210, 240, 270, and 300 after the injection; (B) Titers of virus-neutralizing antibodies to SARS-CoV-2 B.1.1.1 variant, (C) Levels of P2C5-Fс antibody and (D) Titers of rAAV- and P2C5-Fc-specific antibodies in blood serum of the animals. Lines – mean values, n – number of animals per group.