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. 2023 Mar 30;17:1148292. doi: 10.3389/fnbeh.2023.1148292

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Copyright © 2023 Ronan, Korzan, Johnson, Lowry, Renner and Summers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prior stress is necessary to promote icv AVP reduction of 5-HT in the CeA. (A) Similar to CRF, in naïve, unstressed rats, treated icv with saline (N = 7), or 3.0 μg vasopressin (AVP, N = 7) alone do not affect the release of 5-HT in the CeA (condition: p > 0.39; time: p > 0.6; condition x time: p > 0.77; GLM-TWRMANOVA). (B) The combination of stress prior to icv AVP delivery (N = 8) produces a significant decline in CeA 5-HT release, compared with restraint stress followed by saline (N = 7; time: p ≤ 0.0343; GLM-TWRMANOVA).