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. 2023 Mar 30;14:1149339. doi: 10.3389/fimmu.2023.1149339

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Copyright © 2023 Hu, Huang, Zheng, Zhang, Zeng, Nie, Pang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DE-miRNAs in periapical tissue. (A) Correlation analysis of the sequenced samples. (B) Volcano diagram of DE-mRNAs. (C) Volcano diagram of DE-miRNAs. (D) Circular heatmap of 12 up-regulated and 6 down-regulated miRNAs. (E) KEGG pathway enrichment analysis of the intersection genes between the DE-mRNAs and the predicted target genes of DE-miRNA. (F) Relative expression of the seven miRNAs in samples of periapical tissues (AP/Control:23/13). Data were presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, ns, no significance.