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. 2023 Mar 30;14:1149339. doi: 10.3389/fimmu.2023.1149339

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Copyright © 2023 Hu, Huang, Zheng, Zhang, Zeng, Nie, Pang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of IFIT2 can reverse the effect of endogenous miR-199a-5p reduction on osteogenesis. (A) The knockdown efficiency of the three pairs of IFIT2 siRNAs. (B) ALP staining after 3 days of osteogenic induction (scale bar = 400 μm). (C) ALP activity assays. (D) The protein expression levels of RUNX2, ALP, and OPN. (E) The relative mRNA expression level of osteogenic marker genes RUNX2, OSX, ALP, and OCN. (F) ALP staining after 3 days of osteogenic induction (scale bar = 400 μm). (G) ALP activity assay. (H) The protein expression levels of RUNX2, ALP, and OPN. (I) The relative mRNA expression level of osteogenic marker genes RUNX2, OSX, ALP, and OCN. (J) The CCK-8 assay. The data were shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.