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. 2023 Mar 30;14:1149339. doi: 10.3389/fimmu.2023.1149339

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Copyright © 2023 Hu, Huang, Zheng, Zhang, Zeng, Nie, Pang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of miR-199a-5p enhances hSCAPs osteogenic differentiation in vivo. (A) Left: Representative micro-CT images of 3D reconstruction and sagittal profiles of bone formation in β-TCP scaffolds of miR-199a-5p mimics (n = 3) and NC groups (n = 3). The blue areas: the region of new bone formation. Right: Quantitative analysis of BV/TV (%). The data were expressed as mean ± SD. *p < 0.05. (B) Representative images of H&E staining, Masson’s trichrome staining and immunohistochemical staining of OCN. The black arrows: bone formation. The triangle: positive cells.