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. 2023 Mar 30;14:1164278. doi: 10.3389/fimmu.2023.1164278

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Copyright © 2023 Xing, Lv, Zhu, Cong, Bian, Zhang, Gu, Chen, Tan, Su and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gelsevirine decreased inflammatory activities of microglia with limited toxicity to major types of cells from brain in vitro. (A) Gelsevirine did not decrease the viability of primary neuron, astrocyte and BV2 in vitro. (B, C) Gelsevirine downregulated cell proliferation of BV2 cells induced by LPS or OGD neuron-conditioned medium (named CM). (D, E) Gelsevirine decreased the level of inflammatory facts upregulated by LPS or CM. (****, compared with untreated group, P < 0.0001; ####, compared with LPS or CM treated group, P < 0.0001; ###, compared with LPS or CM treated group, P < 0.001; ##, compared with LPS or CM treated group; #, compared with LPS or CM treated group, P < 0.05; ns, compared with CM or LPS treated group, P > 0.05; n = 3).