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. 2023 Mar 30;14:1164278. doi: 10.3389/fimmu.2023.1164278

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Copyright © 2023 Xing, Lv, Zhu, Cong, Bian, Zhang, Gu, Chen, Tan, Su and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gelsevirine deceased brain damage and improved neurological functions in tMCAO model mice. (A) Molecular structure of Gelsevirine and the design of animal experiment. (B) Functional scores were used to evaluate the benefit effect of Gelsevirine on the treatment of stroke, and (C) the ability of motor and balance was found significantly rescued by the administration of Gelsevirine in rotarod test. (D) Analysis of the infarct volume by TTC staining also proved the protective effect of Gelsevirine on neuron in tMCAO model mice. (E) Gelsevirine decreased neuron loss in ischemia penumbra zone (in immunofluorescence n=9-10; in function test and TTC n=12; ****, compared with sham group, P < 0.0001; ## compared with Vehicle, P<0.01; # compared with Vehicle, P<0.05).