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. 2023 Mar 30;14:1164278. doi: 10.3389/fimmu.2023.1164278

Figure 3.

Figure 3

Gelsevirine deceased activity of microglia in tMCAO mice and NFκB pathway, autophagy pathway and ROS-related signal pathway in CM treated BV2 cells. (A) In the ischemia penumbra zone of tMCAO mice, microglia were significantly activated by sholl analysis on morphologic characteristics and the activity of microglia could be decreased by Gs. (B) In the ischemia penumbra zone of tMCAO mice, increased expression of iNOS in microglia was significantly downregulated by Gs. (C, D) In vitro, Gs decreased the expression of inflammatory cytokines and inflammatory related signaling pathways in CM stimulated microglia model (****, compared with sham group or untreated group, P < 0.0001; ***, compared with sham group or untreated group, P < 0.001; *, compared with sham group or untreated group, P < 0.05; ####, compared with vehicle group or CM group, P < 0.0001; ###, compared with CM or Vehicle group, P<0.001; ##, compared with CM or Vehicle group, P<0.01; #compared with CM or Vehicle group, P<0.05; ns, compared with CM or Vehicle group, P > 0.05; n=3.