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. 2023 Mar 30;14:1164278. doi: 10.3389/fimmu.2023.1164278

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Copyright © 2023 Xing, Lv, Zhu, Cong, Bian, Zhang, Gu, Chen, Tan, Su and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gelsevirine rescued the level of mitochondria-related damage and ROS. (A) Gs rescued levels of MDA and SOD in MCAO mice. (B) The administration of Gs significantly decreased ROS by the stimulation of CM. (C) Accumulation of autophagy-related protein to mitochondria was attenuated by administering Gs in CM treated BV2 cells. (D) Gs increased the expression of Nrf2, an antioxidant gene and downregulated the expressions of iNOS, p-mTOR and LC3 which are tightly related to the ROS and autophagy. (****, compared with sham group or untreated group, P < 0.0001; **, compared with untreated group, P < 0.01; *, compared with untreated group, P < 0.05; ####, compared with CM group, P < 0.0001; ###, compared with sham group or CM group, P < 0.001; ##, compared with sham group or CM group, P < 0.01; #, compared with CM group, P < 0.05; ns compared with CM group, P > 0.05; n = 3).