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. 2023 Mar 30;14:1164278. doi: 10.3389/fimmu.2023.1164278

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Copyright © 2023 Xing, Lv, Zhu, Cong, Bian, Zhang, Gu, Chen, Tan, Su and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gelsevirine decreased the JAK2-STAT3 signal pathway by inhibiting the activity of JAK2 in vitro. (A) Gelsevirine significantly decreased phosphorylation of STAT3 in CM-induced microglia in vitro. (B) Molecular docking indicated the potential inhibition of Gelsevirine on JAK2 and (C) Gelsevirine inhibited the kinase activity of JAK2. (D) Gelsevirine inhibited the degradation of JAK2 in thermal shift assay. (E) Gelsevirine inhibited the nuclear distribution of STAT3 in vitro. (****, compared with untreated group, P < 0.0001; ####, compared with CM group, P < 0.0001; ns compared with CM group, P > 0.05; n = 3).