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. 2023 Mar 25;27(8):1131–1143. doi: 10.1111/jcmm.17727

FIGURE 5.

FIGURE 5

Serum‐Exosome‐treated M1 macrophage‐CM promotes angiogenic differentiation of HUVEC via VCAM1. (A) Heatmap of differentially expressed genes in HUVEC. (B) KEGG pathway enrichment analysis of differentially expressed genes. (C) Gene Set Enrichment Analysis of DEGs of TNF signalling pathway in HUVEC. (D) Gene set heatmap of TNF signalling pathway. (E) RT‐qPCR analysis of VCAM1 and EMCN expression in HUVEC (n = 3). Representative Western blot images (F), and quantification (G) of angiogenic differentiation markers (n = 3). CPD323: VCAM1 inhibitors. Significant difference between the groups, *p < 0.05, **p < 0.01, and ***p < 0.001.