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. 2023 Mar 25;27(8):1131–1143. doi: 10.1111/jcmm.17727

FIGURE 6.

FIGURE 6

Human serum‐Exosome promotes osteogenesis and angiogenesis in rat mandibular bone defects. (A) Representative micro‐CT sectional view of the healing of mandibular bone defect in rats and quantitative analysis of newly formed bone parameters (n = 5). (B) Representative microscopic images of Haematoxylin & Eosin stained tissue sections and quantification of newly cortical bone thickness (n = 5). (C) Representative microscopic images of Masson Trichrome stained tissue sections and quantification of Masson stained newly formed bone (n = 5). (D) Representative microscopic images of immunohistochemistry of tissue sections and quantification of iNOS, CD31 and VCAM1 expression (n = 5). S: Bio‐Oss scaffold; white arrow: newly formed blood vessel. Significant difference between the groups, **p < 0.01 and ***p < 0.001.