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. 2022 Nov 9;72(12):589–605. doi: 10.1111/pin.13287

Figure 4.

Figure 4

The PBG is a site of origin of papillary tumorigenesis in EHBDs of the iFGF10 mouse model. Cell lineage tracing of Sox9‐ and Pdx1‐expressing PBG cells during the progression from normal to papillary (IPNB‐like) lesions development in I FGF10 mice. Photos of X‐gal staining the in Sox9‐iFGF10 model (LSL‐rtTA; Sox9‐CreERT2; Tet‐Fgf10) and Pdx1‐iFGF10 model (LSL‐rtTA; Pdx1‐Cre; Tet‐Fgf10) crossed with LSL‐LacZ reporter mice. Dates indicate 1 day, 1 wks (weeks), and 1 M (month) since the start of Dox administration after marking the Sox9‐ or Pdx1‐expressing cells. Arrowhead, PBG. Bars, 200 µm. EHBD, extrahepatic bile duct; PBGs, peribiliary glands.