Table 2.
Examples of efflux pumps conferring increased tolerance to quaternary ammonium compounds. Cite at line 238
| Pathogen | RND | MFS | ABC | SMR | MATE | PACE |
|---|---|---|---|---|---|---|
| E. coli | AcrAB-TolC | MdfA(Cmr), EmrB, EmrD | EmrE, SugE | NorM, MdtK/YdhE | ||
| Pseudomonas | Mex-Opr | QacE△1 | PmPM | |||
| Serratia | SdeXY, SdeAB, SdeIJ, | SmfY | ||||
| Burkholderia | Mex-Opr-like | AceI | ||||
| Acinetobacter | QacA, QacB | QacE, QacE△1 | PmPM | AceI | ||
| Achromobacter | ||||||
| Proteus | PmPM | |||||
| Vibrio | PmPM | |||||
| Aeromonas | QacE2 | |||||
| Enterobacter | acrB | SugE | EmmdR/YeeO | |||
| Klebsiella | QacE | |||||
| Salmonella typhimurium | AcrAB-TolC | |||||
| MFS | ABC | SMR | ||||
| S. aureus |
NorA, QacA, Qac B; MepA MdeA |
EfrAB | QacC,QacG,QacH, QacJ, QacE△1 | |||
| L. monocytogenes | EmrELm | |||||
| Enterococcus | QacA/B | EfrAB | QacC, QacE△1 |
RND = resistance-nodulation-division; MFS = major facilitator superfamily; ABC = ATP-binding cassette; SMR = small multidrug resistance; PACE = proteobacterial antimicrobial compound efflux; MATE = multidrug and toxic compound extrusion